Nevertheless, blocking the effects of type I IFNs with antibodies resulted in a loss of the priming of IL-12p70 induction, showing that type I IFNs mediated the priming.
Finally, we showed that type I interferons were primarily responsible for the priming of IL-12p70 that was observed by infection with IAV.
Hence, bacterial uptake, processing of the internalized bacteria and the number and viability of SP determined whether IL-12p70 was produced by MDDCs, while a priming of IL-12p70 induction was only found after infection with replication-competent IAV.
To determine whether the IAV-dependent priming of IL-12p70 expression after subsequent SP infection was mediated by a secreted factor, we performed supernatant transfer experiments where supernatants from mock-and IAV-infected cells were transferred to fresh MDDCs and the level of cytokine secretion was determined.
In the present study, group in whom integrated arterial filters were used, a prime volume of 1450 cc was used, while in the nonintegrated group a prime volume of 1650 cc was used.
Prime Movers Rattigan, who, thanks to his centenary this year, appears to be the prime mover of 2011 in general.
Like Conor Oberst in the prime of his early-2000s Bright Eyes purge, Gareth is a welcome raconteur whose tone may sound skittish, but who's actually confidently snide.
Bunis later wrote on senior tennis for Tennis Magazine and, with Roger Williams, wrote "How to Play Winning Tennis in the Prime of Life" (1983).
Thatcher became Prime Minister of May , 1979
Willie Mitchell, who has died aged 81, was the prime mover of 1970s Memphis soul music.
There will be no such letters written by the prime ministers of tomorrow who are adolescents today.
