"prime challenge" is correct and usable in written English and can be used to refer to a particularly difficult or complex problem or task.
For example: "Solving this prime challenge will require us to think outside the box."
P27 Financial Times Amazon's Prime challenge is international growth.
Sustaining these loads is one prime challenge of these implants which is complicated by the need to survive in body electrolytes (proteins, enzymes, salts) that are very corrosive.
The auguries are also dim: 84 per cent of the participants at a recent biopharmaceutical conference in Monaco view funding as the industry's prime challenge.
If Sheffield loses votes because of the Dodgers' failure to contend seriously, Piazza's prime challenge could come from Jeff Kent of San Francisco.
But determining whether the Ordos-style expansion and re-engineering of old cities is being driven by smart planning or propelled by speculative madness is a prime challenge for Beijing policy makers.
Kerry will likely face resistance in seeking lockstep commitments, of course, given that India's prime challenge is bringing reliable electricity and affordable fuels by any means to its billion-plus citizens — some 400 million of whom were unaffected by last year's blackouts because they have no access to electricity at all.
Direct in vivo visualization, in full atomic detail, of the microbial cell wall and its stress-bearing structural architecture remains one of the prime challenges in microbiology.
A prime-challenge protocol using an H9N2 isolate with 98% homology to the internal genes of the A/HongKong/156/97 H5N1 protected against the otherwise lethal challenge (46 ) with a virus with a highly cleavable H5, a characteristic of all the pathogenic H5 viruses.
Even when three live virus immunizations were administered (PR8 primed, challenged with X31 then with PR8), T -Atg7 −/− mice were unable to mount recall responses.
The mRNA abundances of four genes were higher in primed and challenged cells compared to non-primed challenged cells because their E. coli induced downregulation was diminished by priming (Additional file 2, Table S2A, highlighted in green).
No one has ever observed them, however, and their detection is now the prime intellectual challenge for physics in the 21st century, Heuer added.
