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Vaccination that preserved memory CD4+ T cells in primates challenged with SIV [51] led to an increased survival [52], [53].
Similar neural spreading pathways of muscle infection were previously found in hamsters orally challenged with scrapie [28] and suggested by the detection of PrPTSE in muscle fibres and muscle-associated nerve fascicles of clinically-ill non-human primates challenged with BSE prions [29].
Proof-of-concept passive immunization studies in primates challenged with simian-human immunodeficiency viruses (SHIVs) yielded clear-cut evidence of the ability of several neutralizing human monoclonal antibodies (nmAbs) to provide complete protection from infection [9], [10], [11], [12], [13], [14], [15], [16], [17] (reviewed in [18]).
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Protection has been induced by MSP3 in primates challenged by P.falciparum [16].
We conclude that TSV did not infect the primate cells challenged with TSV in our study.
This method was then used for downstream profiling of plasma miRNAs found in archived samples from one nonhuman primate (NHP) experimentally challenged with Ebola virus by the aerosol route.
Three lines of primate cells FRhK-4, MA-104, and BGMK, which are highly susceptible to infection by human picornaviruses, were challenged with TSV.
Vaginal and rectal exposure models in non-human primates have shown the feasibility of tenofovir as a topical microbicide and oral PrEP by protecting the majority of the animals challenged with SHIV [17], [18], [54].
and challenged with cocaine.
To date, immunization strategies inducing cytotoxic CD8 T cells (CTLs) have impressively mitigated the severity of infection in nonhuman primates following challenge with SIV or SIV with an HIV envelope (SHIV), but have not prevented the acquisition of infection.
Thus, primate challenge models should test vaccine safety and efficacy also in relation to this route (reviewed in [21]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com