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Hundreds of primary translation products, as well as post-translational modifications, have so far been identified using a combination of procedures that include mass spectrometry, two-dimensional gel immunoblotting, and cytokine and signalling pathway-specific antibody arrays.
Genomic research has revealed that HIV has a compact genome, which consists of nine open reading frames (leading to nine primary translation products) that code for fifteen different translational products, represented by nineteen proteins.
The deletion of two nucleotides in RNAP gene truncates the primary translation due to early stop codon, while a second translational peptide starting from GTG just at deletion point can remediate the polymerase activity.
HEF is synthesized on membrane-bound ribosomes and the primary translation product is subjected to a series of co- and post-translational modifications, most of them are required for proper folding and/or functioning.
The initial protein species is the primary translation product.
One would expect that, usually, one distinct transcript would lead to one distinct primary translation product.
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Although the conclusion is indeed correct, unfortunately this elimination result would be too weak for his algebra of logic if he only used his primary translations into equations.
The unstressed berry cluster possessed overrepresented transcripts encoding genes with functions involved in primary metabolism, translation, cell wall-related proteins (9%), and transport (12%).
More than 200 point mutations cause β-thalassemia [ 10] and can affect transcription, splicing of the primary transcript, translation, and stability of the β-globin mRNA.
For down-regulated genes, we found significant enrichment for genes associated with primary metabolism, translation, response to light, abiotic stress and biotic stress.
Subsequent analysis demonstrated the primary PF3D7_1423300 translation product to be much larger than the PP catalytic domain, with two EF-hand motifs that must be occupied by Ca2+ for the enzyme to become fully active [ 57].
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