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Unsupervised hierarchical clustering of gene expression produced two major groupings: diagnostic leukemia cells and normal leukocytes formed two discrete clusters (Figure S1), with 58% of the genes exhibiting discordance in gene expression (p<0.001) between the two primary tissue types.
We have mapped genome-wide nucleosome organization in two mouse primary tissue types, providing an important resource for the understanding of chromatin structure and gene regulation.
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Of the two primary hypothesized brain structures and tissue types, one, namely bilateral frontal white matter (FWM), showed no significant volumetric group differences.
On one of the prostate cancer dataset studied (obtained from a previous published study, [44]), we observe a gradual pattern of reduction of Normalized Shannon Entropy from three well characterized tissue types: normal prostate, primary prostate tumours and lymph node metastases.
Though it is possible that some cartilage network orthologs are re-deployed together after metamorphosis, we view this as unlikely since most amphioxus tissue types, including the primary gill bars, form during larval stages[44].
To assess univariate differences in gene expression across prostate tissue types (normal tissue, primary tumors, and metastatic tumors), we performed t-tests for each gene with multiple testing corrections.
It has been recognized previously that in terms of cell types and tissue types along the primary body axis, sponges are much simpler than bilaterians (i.e., sponges lack true tissues and organs) and that cnidarians occupy an intermediate level of axial complexity [ 29].
Typical of nearly all primary cell cultures, the growth of non-immortalised primary cell cultures diminished significantly for most tissue types after approximately 10 passages.
RFC1 functions as a facilitative anion exchanger and the primary transporter of reduced folates in multiple tissue types.
We identified DCD splice variant (DCD-SV) that is co-expressed with DCD in primary invasive breast carcinomas and in other tissue types and cell lines.
We next sought to determine whether CDKAL1-v1 is similarly regulated in human pancreatic islets the primary tissue of interest with respect to the type 2 diabetes association.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com