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The primary target cells for the human immunodeficiency virus (HIV) infection in the genital tract are CD4 T cells that express CCR5 on the surface.
Primary target cells for IV infection in humans are respiratory epithelial cells [7].
Fc-mediated antiviral activity did not appear to influence infection of primary target cells in cervical explants.
CD4 T-cells in gut-associated lymphoid tissue (GALT) are primary target cells of HIV, and GALT is an important site for HIV replication and pathogenesis [1] [4].
Macrophages, in particular, have been hypothesized to be critical for the pathogenesis and spread of smallpox; as one of the initial primary target cells, circulating macrophages are believed to deliver virus to a variety of other target cells and tissues.
Since these cells are the primary target cells for virus production, it is likely that the ability of virus to escape drug pressure declines proportionally with the decline in these cells [14].
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Tumor cells have long been the primary target cell type of liposomes for anticancer therapy.
Second, it is not clear for many of these mechanisms whether the primary target cell is the effector T cells and/or DCs or other antigen-presenting cells.
Therefore, the primary target cell of the indomethacin pre-treatment was the endothelial cell.
These results demonstrate that the Sertoli cell-enriched testis is capable of carrying out the sequence of biochemical events previously described for FSH in the normal testis and therefore, suggest that the Sertoli cell is the primary target cell for FSH action.
These results indicate that the ciliated cell, rather than the goblet or the basal cells, is the primary target cell for the AIV.
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