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"primary symptom" is a perfectly acceptable phrase in written English.
You can use it to refer to the main or dominant symptom of a particular illness. For example, "The primary symptom of the flu is usually a fever."
Exact(60)
Tics can be the primary symptom.
It is a disease with its primary symptom fatigue.
The primary symptom of appendicitis is abdominal pain.
Back pain is a primary symptom of the disease.
Current treatments for claudication, the primary symptom in patients with PAD, have limitations.
Instead, the imbalances were a primary symptom of forces that led directly to the financial crash.
"They can't remember from one moment to the next". Anhedonia: The primary symptom is an inability to feel pleasure.
The primary symptom is myotonia, a stiffening of the muscles after use.
Vision that immediately translates nature into dollar signs is a primary symptom of the epidemic that is sweeping San Francisco in "Sly Fox".
We gradually realize, however, that his primary symptom is an alarming fixation on the sexuality of his religious 13-year-old sister, Nabisase.
An obstetric fistula is a rupturing in or near the vagina, frequently caused by difficult childbirth, with a primary symptom being incontinence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com