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In this study, 173 cervical cancer and 306 cervical intraepithelial neoplasia (CIN) cases were prospectively collected from patients who enrolled in Gangnam Severance Hospital, Yonsei University College of Medicine from March 1996 to March 2010, and received primary surgery during that time.
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The recurrent tumours in three patients who showed relapse within 4 months after the primary surgery or during the first 3 or 4 cycles of adjuvant FOLFOX therapy (cases 1 3) were regarded as synchronous metastases arising from micrometastases that likely existed prior to the start of the adjuvant chemotherapy.
However, survival tended to be better after complete cytoreduction during primary surgery than during interval surgery.
Here we present initial proof of concept results for a representative series of 49 population-based breast cancer patients whose primary surgery occurred during the fall of 2011 and that we analyzed in parallel by RNA-sequencing and gene expression microarrays.
Response to platinum-based chemotherapy could only be evaluated in patients who had measurable disease after primary surgery and/or during first-line chemotherapy (n=130), and was defined according to WHO criteria (World Health Organization, 1979).
In six (50%) patients the IOL was explanted, which included four explantations during the primary surgery and in two patients during additional interventions.
Therefore, it is crucial to preserve the main pedicle during primary surgery.
However, repositioning of cleft side dome and lateral crus of lower lateral cartilage could be performed in minimally invasive manner during primary surgery as we presented here.
Of 5 patients, ascites samples were obtained during primary surgery.
Tumor tissue and ascites were obtained during primary surgery prior to any other treatment.
Samples have been collected during primary surgery.
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