Secondary cytogenetic abnormalities can occur in any of the primary subtypes of MM and influence disease outcome to varying degrees.
We provide evidence that CD146 is involved in breast cancer cell line motility and is associated with the basal subtype of primary breast cancers.
Published reports to date have been small and confounded by significant heterogeneity concerning the primary subtype, tumor size and the number of metastases, the number of systemic treatments before and after RT, total dose, and the number of fractions.
This primary subtype composition indicates possible seeding of the Luxembourg MRSA population from both Germany, which has a dominant spa t003, and France, which has a dominant spa t008 [ 8].
Lung adenocarcinoma is the most primary histologic subtype of non-small cell lung cancer (NSCLC).
As seen in Table 3, the prognostic risk is driven primarily by the underlying primary cytogenetic subtype of MM.
Once the primary cytogenetic subtype of MM is identified, with repeat bone marrow examinations carried out at relapse a more limited probe set is adequate, for example: 1p36.3 TP73), 1q21 CKS1B), 8q24 (3'MYC,5'MYC), 17p13.1 (p53), and 17cen (D17cen.
Because SEER data do not capture subtype-specific classifications, such as papillary type 1, and papillary type 2, these additional levels of stratification were not examined for any of the three primary subtypes.
We evaluated the classification method on a gold standard derived from the PubMed Supplementary Concept annotations, achieving a micro-average F1-score of 85.9% for primary subtypes.
One or more of these can occur in any of the primary cytogenetic subtypes of MM.
