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Cost prices from the primary study will be actualised and used in this study.
A large primary study will be necessary to confirm our study and validate the therapeutic response in the depression with T2DM patients who carry Met allele.
For each clinical question, evidence profiles based on the results of the treatment effect (of a meta-analysis or a single primary study) will be prepared.
Each primary study will be "inspected for evidence, according to how it supports, weakens, modifies, supplements, reinterprets or refocuses the preliminary theory".
Each primary study will be examined for evidence based on how it supports, refutes, reinterprets or refocuses the novice theories developed in the first step, looking at how each study contributes to refining the initial theory.
Sixty-four healthy participants, age and gender matched to the first 64 people with Alzheimer's disease in the control group of the primary study, will be recruited from community advertisements such as newsletters and existing volunteer databases (ie the National Ageing Research Institute database).
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Using both published and unpublished primary studies, we therefore argue that the effect sizes of the high-quality primary studies will be higher than the effect sizes of the low-quality primary studies.
Primary studies will be excluded if they were observational studies or before-after studies with historical controls.
Two independent reviewers (SCS and SP) will conduct data analysis and the primary studies will be combined, compared and contrasted to generate meaning that extends beyond any individual study using thematic analysis in a Grounded Theory framework.
The study findings indicate "that it is possible, but not probable, that the primary endpoint of the study will be achieved," Dendreon's chief executive, Christopher S. Henney, said in a statement.
The primary outcome for this study will be a composite measure of major neonatal morbidities (necrotizing enterocolitis, retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular hemorrhage, and mortality).
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CEO of Professional Science Editing for Scientists @ prosciediting.com