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These results are in line with those of the primary study, which showed that rSBA GMTs against each serogroup were statistically higher at one month post-MenACWY-TT vaccination compared with MenPS.
Foremost, we would like to thank Dr Ciara Mulligan (formally McLaughlin) who was responsible for the recruitment and running of the primary study, which provided the samples for these secondary analyses.
Thus, treatment success (versus failure) was defined according to the success outcome reported in the primary study, which could be a β-hCG urine or blood test ≤21 days after embryo transfer, an ultrasonographic visualization of fetal heart activity or a live birth, as per standard definitions (Zegers-Hochschild et al., 2009).
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Systematic reviewing of laboratory data is expected to result in better, bigger and more reliable primary studies, which hopefully will support the diffusion of new diagnostic technologies with scientifically proven efficacy and effectiveness in the future.
Frosi et al. (2014) come to a similar conclusion and state that this is especially true in the case of missing outcomes in the primary studies, which underlines the validity of our multivariate results and supports the approach to be used in further applications.
Nevertheless, further research is needed, to provide more adequate primary studies which account for confounding and other biases.
Guion (2011) expresses serious doubts about using very old primary studies (which he refers to as "rancid data").
We identified 13 primary studies which evaluated the effects of an intervention to improve generic drug utilisation.
There are methodological restrictions in data quality of primary studies, which have to be considered when interpreting the results.
Moreover, pooling observational studies, this review cannot overcome the limitations of primary studies, which were of relatively high quality, but still none was based on randomized allocation [ 26].
However, reviewers of only three papers (S1, S16, S28) judged the conceptual richness of primary studies, which was done to exclude descriptive studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com