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In the case of duplicated publications and companion papers of a primary study, the yield of information was maximized by simultaneously evaluating all available data.
In more than half of the meta-analyses that accompanied a primary study, the investigators did not even specify what databases they had searched.
The primary study, the Erlangen Glaucoma Registry (EGR; ClinicalTrials.gov number NCT00494923), is concerned with subjects at risk for glaucoma and patients with manifest glaucoma, its special focus being the predictive value of diagnostic tests.
In order to determine reproducibility of the results of the primary study, the follow-up study, reported here, was designed with the use of a different model and a distinct claims database.
In the primary study, the authors investigated the effects of higher versus lower intensity balance, strength and walking exercises on rehabilitation inpatients after surgical fixation for a hip fracture [ 16].
Briefly, the aim of the primary study (the COACH trial) was to determine whether a coaching intervention delivered by a geriatrician and specialist nurse in a post hospital (intermediate) care setting improved older adults' and carers' assessment of the quality of preparation for transfers.
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The fifteen reviews included a total of 265 different primary studies, the number of primary studies included in an individual review varying from 8 [ 98] to 71 [ 81].
In this analysis the river cities form the primary study and the non-river cities the control sample.
While several primary studies analysed the effects of flexible work schedules, few primary studies analysed the effects of telecommuting and hardly any primary study analysed the effects of sabbaticals.
Moreover, some primary studies report the statistics for the proxy variables based on different samples.
The primary study endpoint was the 72-hour area under the curve for plasma lutein (AUC0-72h).
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