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A primary study limitation is the cross-sectional design that does not allow us to infer causal relationships between rhythm disturbances and mood state.
The primary study limitation is that we were unable to conduct full blood panel testing for nutritional deficiencies, and are therefore limited to considering haemoglobin as our sole indicator of micronutrient deficiency.
The primary study limitation is that the data are derived from an observational cohort and not from randomized groups so that patients receiving TNFα inhibitors had more severe disease at baseline.
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The authors also collected information on the included participants, adverse events, study limitations, the primary outcome of interest and whether the intervention had been retested.
Because this meta-analysis is based on observational studies, the inherent limitations of primary studies may have affected our findings.
There are some limitations of primary studies included that may have influenced on the results of the meta-analysis.
Beyond selective reporting, existing meta-analyses have not addressed limitations in primary studies from including already diagnosed and treated patients in study samples.
Moreover, pooling observational studies, this review cannot overcome the limitations of primary studies, which were of relatively high quality, but still none was based on randomized allocation [ 26].
This would also make it easier to pinpoint the nature of reporting limitations in primary studies by making transparent the discrepancies between what reviews intended to measure and what information was not available in primary studies.
Our studies primary limitation is sample size, and although our breast centre specializes in treatment of locally advanced breast cancer; with increased screening and education this is becoming a rare diagnosis.
The primary potential limitation of the study is the self-reported health status of the adult daughters.
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CEO of Professional Science Editing for Scientists @ prosciediting.com