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The primary study design is that of a cost consequence analysis (CCA) [ 33].
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The primary study design was a randomized, controlled trial of one drug vs placebo/usual care.
The inclusion criteria for primary study design were also inconsistent; 3 reviews (including the IQWiG review) considered both RCTs and non-RCTs, and 2 reviews considered only RCTs.
The primary study designs were surveys (61, 45%), interventional studies, with the intervention being the implementation of RDH restrictions (52, 39%) and observational studies (8, 6%).
The primary advantage of our study design is the possibility of documenting concerns within the community before and after the disaster, as a significant limitation in disaster studies is often the lack of baseline data [ 12].
The use of a single group, pre-post study design is primary among these.
The ecological study design is a primary limitation of our study because we could not adjust adequately for individual level covariates such as consumption of meat and vegetables, which might confound the association of CRC with THM concentrations.
The primary aim of our study design was to acquire enough samples to achieve statistically significant results for the identification of common, low penetrance alleles in CRC.
(1) The single primary outcome variable of our study design was Length of Stay (LOS), the number of days in the intensive care unit from day of birth to day of discharge home.
The primary study design has been published previously.
ND participated in the study design, was the primary data collector, oversaw database management, contributed to results interpretation, and drafted the manuscript.
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