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The primary study design was a randomized, controlled trial of one drug vs placebo/usual care.
While there is a lot focus on primary study design much less is focused on patient eligibility and to what extent the patients included in a clinical trial are representative for the patients treated in "real life".
By its synthesis of a selected portion of the continuing medical education (CME) literature, the evidence-based practice center (EPC) review discovered several major issues in primary study design and in the systematic review process of CME studies.
The primary study design has been published previously.
JGM was responsible for primary study design and supervision of data collection.
JGM was responsible for the primary study design and supervision of data collection.
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Are the primary study designs and number of studies clearly stated?
Therefore the primary study designs of relevance included: case control, cohort, case crossover, or cross sectional research methodologies.
3. Are inclusion/exclusion criteria stated? 4. Are the primary study designs and number of studies clearly stated? 5. Have the primary studies been quality assessed?
The primary study designs were surveys (61, 45%), interventional studies, with the intervention being the implementation of RDH restrictions (52, 39%) and observational studies (8, 6%).
The systematic review methodology has several key principles: transparency, comprehensiveness and evaluation of the primary research study design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com