Sentence examples for primary selective pressure from inspiring English sources

As the primary selective pressure implicated in the genomic reductions for this oligotrophic lineage is to lower the cost of such scarce nutrients for cell production [5], [22], [23], [82], [83], it is reasonable that such a gene would be lost in the absence of selective pressure for its retention.

In the future, these factors will have to be considered along with the primary selective pressure from the pathogen environment.

Like previous researchers (e.g., Darwin 1875; Belyaev 1974; Trut 1999), we begin with the assumption that a primary selective pressure during the initial stages of domestication is on behavior, and in particular for tameness (lack of fearful or aggressive responses to human caretakers).

Androgens, for example, mediate proliferation, apoptosis, oxidative stress, and perhaps inflammation in the prostate, and are therefore likely primary mediators of selective pressure in the evolution of prostate cancer.

However, these cells usually differ from primary macrophages, as the selective pressure imposed by continual subculture usually results in the loss of genes that are not important for multiplication yet are key for macrophage immune functions.

The reasoning behind such approaches is that motifs of critical functional significance are expected to be more highly conserved than benign stretches of primary sequence free from selective pressure.

In 7 out of 14 (50%) cases, we observed a significant reduction in CEBPδ mRNA in the metastasis relative to the primary cancer, consistent with selective pressure for loss of CEBPδ expression with acquisition of a metastatic phenotype in breast cancer.

As mentioned in the revised manuscript, we specifically chose to use primary tumor cultures of low passage rather than tumor cell lines, because the latter have been subject to much more selective pressure as primary tumor cultures of low passage.

Third, it is possible that the synthesis of anti-viral CCR5 ligands early in the primary immune response contributes a selective pressure to generate the latent viral reservoir in resting CD4+ T cells [35], [36].

The selective pressure within the primary carcinoma that led to the formation of progressor mutations is still to be revealed [ 34].

Interestingly, the metastatic tumor looks genetically less heterogeneous compared with the primary tumor, suggesting that a strong selective pressure at the ectopic site likely prevented further genetic heterogeneity from developing during the metastatic growth.