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Selection intensity (i) was held constant, with truncation selection, and in such schemes the primary selective advantage is the individual's breeding value or its components (the EBV and prediction error) [ 16].
It has been postulated that the primary selective advantage of the broadly occurring high-frequency sensitivity in mammalia is that it enables the use of binaural spectral-difference cues to localize sound [5], [30].
My second comment relates to the primary selective advantage attributed to the acquisition of PAL from bacteria, which might have been the production of antimicrobial or pigmented metabolites that would allow the successful competition of land plants/fungi in soils or protection against UV light.
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Using ecological principles from migratory animal populations, modeling studies have shown how migratory ability, by increasing the ability of a cancer clone to sample different environments with variable resources in the primary tumor, can provide a selective advantage within the primary tumor by allowing the cancer cell clone to experience more favorable environments (Chen et al. 2011).
This suggests that some driver mutations, acquired within or outside the primary tumor, confer selective advantages for survival and expansion of cancer cells outside the primary tumor.
We then analyzed if maC46 could also confer a selective advantage to primary human T lymphocytes in HIV-1-infected cultures.
We have previously shown that viral escape is significantly more rapid (higher selective advantage) in primary infection than in chronic infection [30]; this is also a feature of the dataset studied here (P = 0.003, Mann-Whitney two-tailed) which has considerable overlap with the earlier dataset.
The overexpression of Twist-1 may thus be a selective advantage for a primary tumour cell to survive in settings of limited survival signals when contact with the original tumour is lost.
This may also partially explain our observation that variants with a large selective advantage are seen in primary infection.
The frequency and degree of TP73 overexpression in primary medulloblastoma strongly suggests the acquisition of selective advantage(s).
Next, we aimed to identify genes that when mutated provide a substantial selective advantage to SPs in primary and recurrent GBM.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com