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Understanding the mechanisms of the interaction between a protein surface and its outer molecular environment is of primary relevance for the rational design of new drugs and engineered proteins.
Second, it is important to note that, due to the lack of a suitable model for studying KSHV lytic replication in endothelial cells, our model is based on experiments performed in PEL cell lines and, as such, it has primary relevance for KSHV-associated lymphoproliferative disorders.
The distinction between our position and that of Forterre that is of primary relevance for the conclusions of this study is the adoption of different scenarios for the origin of eukaryotes.
Another important factor is remaining life expectancy (Ko and Sonnenberg, 2005; Lin et al, 2006), which is of primary relevance for a potential upper age limit for CRC screening.
Lipids are of primary relevance for membrane functionality at high temperatures; in fact, it has been suggested that the reason why there are no known extreme eukaryotic thermophile can be attributed not only to their susceptibility to mRNA degradation, but also to the susceptibility of their lipids to changes in permeability and phase-state when exposed to high temperatures [ 97].
Overvaluation of shape and weight can be thus considered either a diagnostic specifier or a dimensional severity rate, with a primary relevance for diagnosis, treatment choice, global impairment and outcome, and it can also be considered as a specific target for psychological therapies [ 10, 27, 28].
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The analysis emphasizes the benefits of the EBD method for public health problems which are not of primary relevance.
For most participants, physical aspects of addiction do not seem to be of primary relevance.
This criterion should represent a reasonable indicator of distress, with relevance for primary care.
We feel that these results are of great relevance for primary care interventions among people experiencing poverty and living with chronic illness.
In conclusion, this study on the verification of relations of predefined dietary patterns to diabetes risk suggests that diet quality is of high relevance for primary prevention of type 2 diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com