Cbt association around the TSS may be an indication of its function as a primary regulatory element, but does not provide any information about its role as an activator or a repressor.
* p < 0.005 Very interestingly, however, secondary structure of precursor miRNA showed statistically significant differences such that precursor structure comparison showed even much smaller p-values than seed sequence comparison, which is believed to be the primary regulatory element of miRNA.
The primary translational regulatory elements in 5'UTRs include translation initiation motifs [ 11], upstream start codons (uAUGs), and upstream open reading frames (uORFs) [ 12, 13].
Open or accessible regions of the genome are, thus, regarded as the primary positions for regulatory elements [ 21] and have been historically characterized by nuclease hypersensitivity in vivo[ 22].
In addition to the methylation status of regulatory elements, the primary organizational unit of chromatin, the nucleosome, is an important factor impacting the regulatory capacity of the genome.
The primary function of DNA methylation for regulatory elements is to down-modulate gene expression.
In conjunction with this study, our analysis of Module 1 shows that ARR14 (a MYB family transcription factor) not only recognizes the known primary cis-regulatory element AGATA/TCG but also can specifically bind to a previously unknown cis-regulatory element AGATCT.
The primary focus of our investigation was transcriptional regulatory elements in introns.
We produced a series of duplications and inversions that modify the distance and order of regulatory elements, without changing their primary sequence, and identified multiple configurations that led to mis-expression of Sonic hedgehog.
RNAPII is recruited to active enhancers on a global scale (Szutorisz et al., 2005; Koch et al., 2008; Kim et al., 2010), and we performed RNAPII ChIP-seq in primary hMSCs to annotate putative cis-acting regulatory elements during human adipocyte differentiation.
