Under oxidant stress, many critical proteins regulating endothelial function undergo oxidative modifications that lead to ED. Cellular levels of glutathione (GSH), the primary reducing source in cells, can significantly regulate cell function via reversible protein thiol modification.
Glutathione (GSH) is the primary reducing agent in living cells, with an intracellular concentration of up to 10 mM, depending upon the intracellular compartment and the cell cycle.
Altered energy metabolism, as indicated by reporter metabolites (i.e. ubiquinone-6, ubiquinol-6, mitochondrial proton) and subsystem (oxidative phosphorylation), is certainly feasible as NADH is a primary reducing agent for ATP production.
The presence of two northern candidates for the P.D.P. primaries reduces his chances of winning their support.
In all perching birds the 10th (outermost) primary is reduced to some degree, and in many families only 9 may be found.
Net primary production reduced in crop and rangelands.
In primary TSCC, reduced SOD2 expression is associated with presence of lymph node metastasis.
They found that improved access to primary care reduced stroke admissions.
29 The prevailing structure of primary healthcare reduced GPs' ability to respond to the needs of patients with multimorbidity.
