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Discovered first in rice, GID1/GID2 genes encode the nuclear localized primary receptor of GA (Gomi et al., 2004; Ueguchi-Tanaka et al., 2005; Griffiths et al., 2006; Ueguchi-Tanaka et al., 2007).
In the early 1980s, HIV was discovered as the cause of the life-threatening acquired immunodeficiency syndrome (AIDS), and soon CD4 was identified as the primary receptor of HIV.
The primary receptor of ANP, natriuretic peptide receptor-A (NPR-A) is localized mostly in the kidney, but also is found in hypothalamic area involved in body fluid volume regulation [1], [2], [3].
The entry of SARS-CoV into cells is mediated through interaction between spike (S) glycoprotein of the virus and angiotensin-converting enzyme 2 (ACE2), the primary receptor of SARS-CoV on the host cell [17].
An important cell-surface protein is CD4, the primary receptor of HIV-1.
In this strategy, microbeads are coated with the primary receptor of AAV2, heparan sulfate, to which unmodified AAV2 particles are attached.
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Using homologous and heterologous knob-mediated competition assays with recombinant knobs of HAd5, porcine adenovirus type 3 (PAd3), or BAd3, we observed that BAd3 internalization was independent of the primary receptors of HAd5 and PAd3.
Remarkable and unexpected similarities have been revealed between the cell-attachment proteins and primary receptors of adenovirus and the unrelated reovirus, and between the capsid proteins and architecture of adenovirus, the enveloped bacteriophage PRD1 and other large DNA viruses.
Sensory hair cells in the inner ear are the primary receptors of auditory and vestibular information, and their degeneration causes hearing loss.
Additionally, several cell components such as integrin α6β1, integrin α6β4 and glycosaminoglycans (GAGs) have been proposed as primary receptors of HPV in the cellular adhesion process [ 18, 19].
The primary receptors of Wnt molecules are the seven-transmembrane Frizzled proteins (FRP), each of which interact with a single transmembrane low-density lipid (LDL) receptor-related protein 5/6 (LRP5/6) (He et al, 2004).
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