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Overlapping signals could promote transcription by recruiting RNA polymerases to the primary promoter sequence.
I am the writer and primary promoter for the scandalous sequel to "What They Don't Teach You At Harvard Business School".
One of these possibilities arises when an additional transcription initiation site (e.g. secondary promoter) is present upstream from the primary promoter of the target gene.
The R-loop could extend into the region of the primary promoter, to interfere with promoter recognition by RNA polymerase and thereby inhibit transcription.
In line with the tradition, estrogen is thought to represent the primary promoter of myoma growth.
In several cases after exaptation the ERV-derived promoters become the primary promoter.
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I've gone on record as saying that oxidative damage is one of the primary promoters of aging (in The Most Effective Ways to Live Longer) and one of the four primary promoters of heart disease (in The Great Cholesterol Myth).
It's incumbent upon the U.S. and its European partners, as the primary promoters of human rights and Internet freedom, to set the right course.
Although removal of the two primary bacterial promoter sequences resulted in a reduction in promoter activity, it did not eliminate bacterial expression.
Our results demonstrate the power of primary cell promoter interactomes to reveal insights into genomic regulatory mechanisms underlying common diseases.
In the first combination, which we call activator primary, the promoter is quiescent in the absence of both regulators.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com