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In this scenario, 26% and 18% of active TB cases are due to primary progression with constant and exponential lifespans respectively.
The median PFS was 6, 8 months while the primary progression was observed in only 14% of patients [ 17].
Of the patients, 24.8% (38 of 153) suffered treatment failure, defined as primary progression or early recurrence within 6 months after termination of primary platinum-based chemotherapy.
Such atrophy may be caused by the primary progression of the degeneration associated with AMD, or secondary to the presence and regression of the CNV.
Dual infection with multiple strains is not considered in this model, but superinfection (i.e., reinfection of a latently infected individual with a different strain, resulting in primary progression to disease with the reinfecting strain) is allowed, as is acquisition of resistance (i.e., change of strain from more susceptible to less susceptible) as a result of therapy.
Secondary endpoints were rate of remission, primary progression, number of patients receiving alemtuzumab, therapy-related mortality, EFS and OS, calculated as the time from registration to the first reported event (PRO, initiation of salvage therapy, additional (unplanned) treatments, relapse or death of any cause) or censored at the most recent assessment date.
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Enrollment was closed early following accrual of 191 patients, based on an interim analysis showing an inferior trend in the primary progression-free survival efficacy endpoint for sunitinib.
A planned interim analysis of efficacy data showed an inferior trend that was unlikely to demonstrate a statistically significant improvement in the primary progression-free survival endpoint for sunitinib as compared with bevacizumab.
It was found that the number of CTC that appeared roughly correlated with the stage of primary tumor progression.
114 (12%) patients experienced a Primary Disease Progression (PDP).
Seventy-two patients (29%) developed the primary outcome (progression of AKI stage or in-hospital death).
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CEO of Professional Science Editing for Scientists @ prosciediting.com