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The primary problem lies with what Jakob Nielsen calls the "lean-forward/lean-back" theories.
The primary problem lies in the estimation of horizontal transition probability matrix (HTPM), one key input of the CMC model.
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It is tacitly assumed that the primary problems lie with the deposition of insoluble Aβ as plaques in the brain, or the toxicity of soluble Aβ, or with the accumulation of hyperphosphorylated tau in neurons and neurites.
Indeed, Hui and Smith (2001) find unreliable estimates for several widely used parametric estimators, which lead them to conclude that the primary problem with the estimates lies in the data rather than in the estimates.
Dehydration is the primary problem for athletes.
School staffs were never the primary problem.
The real problem lies at Yasukuni.
"Ignorance and indolence is the primary problem.
But the big problem lies in enforcement.
But the deeper problem lies elsewhere.
Another problem lies in the character names.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com