Metabolism via the primary pathway, postulated to involve alcohol dehydrogenase, is swamped by exposures to concentrations exceeding 220 ppm.
Postulated primary metabolites were synthesized, not being commercially available.
Postulated primary phenotypes are closely associated with the autistic savant skills and the autistic adherent temperament, and might increase the chance of specific prenatal experiences, named 'autistic imprinting'.
In this study attempts have been made to develop a functional model for the catechol binding site of the human dopamine D2 receptor, with two primary models being postulated based on the presence of a disulfide bridge in the second extracellular loop.
The second hypothesis, based on the overall malformation of the caudal body, postulates a primary defect in the generation of the mesoderm.
The first hypothesis, based on the aberrant abdominal and umbilical vascular pattern of affected individuals, postulates a primary vascular defect that leaves the caudal part of the embryo hypoperfused.
Based on recent findings, we develop a new model for the role of glomalin; we postulate a primary role in fungal physiology and secondarily arising effects in the soil environment that lead to observed correlations of GRSP with soil aggregate stability.
In essence, it is postulated that primary vascular misdistribution leading to skin hypoxia may cause a secondary hypoxic-induced neuropathy.
Marine shales deposited contemporaneously with the Plover formation are also postulated as primary source rocks for the Abadi gas field (Nagura et al. 2003).
Silveira and colleagues demonstrated an enhanced reactive oxygen species (ROS) production in EPS-treated primary muscle cells and postulated an important role for elevated ROS levels in the induction of PGC-1α in these cells [8].
If AD is a primary amyloidosis, as is postulated by the amyloid cascade hypothesis, then reducing Aβ would seem a rationale way to proceed with drug development.
