Sentence examples for primary physiological role from inspiring English sources

The primary physiological role of insulin is in glucose homeostasis.

The primary physiological role of the RyR is to provide a ligand-regulated pathway for the release of stored Ca2+ to regulate a diverse array of cellular processes.

Our work indicates that a primary physiological role of USP5 is not to recycle monoubiquitin for reutilization, but that it may involve disassembly of conjugated ubiquitin to maintain proteasome function.

The discovery of UCP homologues in ectotherms raises the question concerning their primary physiological role in thermoregulation [22], [23], [24], [25], [26].

In that case, it would be also of interest to explore whether platelets release SPARC just after or before the acute event, which could be related to its primary physiological role in the disease.

Of particular note, the primary physiological role of the GLP-1 receptor is to stimulate insulin secretion through the regulation of intracellular cAMP concentrations (Seino, 2012).

In fact, one of the primary physiological roles of the pericardium is to influence cardiac filling dynamics by exerting external constraining forces over the heart (pericardial constraint), thus preventing the heart from over-dilatation, myocardial hemorrhage, or valvular insufficiency [ 53].

The primary physiological roles of FGF-23 are two-fold: it inhibits the reabsorption of renal phosphate, thereby increasing the rate of urinary phosphate excretion, and it suppresses the production of 1,25-dihydroxyvitamin D and increases its catabolism by the kidney, thereby protecting the body from excessive vitamin D exposure [ 29, 30].

However, the primary and physiological role of TAA90K appears to be, according to the current knowledge, in immune regulation.

Additionally, we could detect an INB for SUMO1 in skin epithelial cells (Supplementary Figure S 1).We conclude that the presence of the INB in tissue suggests it may have a physiological role in primary cells.

This inflammasome has largely been studied in the human acute monocytic leukemia cell line THP-1, and its precise physiological role in primary cells is yet to be fully elucidated.