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Sosunov, A. A. et al. Tuberous sclerosis: a primary pathology of astrocytes?
Although there are clear diagnostic differences in the primary pathology of both diseases, i.e., death of dopamine-generating cells in the substantia nigra in PD and neuroinflammation in HIV, neurotoxicity to dopaminergic terminals in the basal ganglia (BG) has been implied in the pathogenesis of HIV and neuroinflammation in the pathogenesis of PD.
Thus, he says, the drug "could be getting closer to the primary pathology" of schizophrenia.
The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis) is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction.
Indeed, it is not know whether the primary pathology of the illness is region-specific or widespread and data has been provided for both cases [10], [36].
The choice of chemotherapy depends upon the primary pathology of the tumor.
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Muscular hyperactivity has been associated with psychogenic factors [ 13- 15] and with primary pathologies of the central nervous system (CNS), as in forms of dystonia [ 16].
The primary pathologies of the patients were acute pancreatitis (one), emergency repair of an abdominal aortic aneurysm (two), appendix abscess (one), probable pulmonary embolism (one), cholangitis following cholecystectomy (one) and respiratory failure (one).
In this article, we restrict ourselves to the primary pathologies of Alzheimer's disease as well as to ischaemic cerebrovascular disease since it is the most common secondary pathological process seen among demented subjects with Alzheimer's disease pathology at autopsy (Snowdon et al., 1997; White et al., 2005; Schneider et al., 2009).
Neurodegenerative diseases that show a primary pathology consisting of inclusions of filamentous tau can be designated as a tauopathy and include diseases like sporadic corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick's disease (PiD), as well as hereditary FTD and parkinsonism linked to chromosome 17 (FTDP-17T).
Cause of death was defined as the primary pathology (irrespective of its duration) leading to death of the patient or to the decision to withhold or withdraw intensive care therapy.
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