Sentence examples for primary pathological changes from inspiring English sources

During the progression of diabetic nephropathy, the primary pathological changes involved fibrosis, impaired renal function, as well as chronic kidney diseases, all of which are known to be associated with a decrease in ADC both in human and in animal studies [13, 14, 15].

Excess chondrocyte apoptosis is one of the primary pathological changes of KBD [ 1, 18].

The primary pathological changes associated with KD include systemic non-specific vasculitis involving both small and medium-sized blood vessels, particularly the coronary arteries, and the possible formation of coronary artery aneurysms, which cause coronary narrowing and thrombotic infarction, resulting in both myocardial infarction and sudden death [ 3].

Reviewer 2: In the present article, Ratte and colleagues investigate the criticality and degeneracy of the pathological changes in primary afferent excitability involved in the aetiology of neuropathic pain.

Histological methods remain the primary tools for the evaluation of pathological changes in tissues in toxicological studies and are gaining considerable attention while conducting sub-lethal exposure of different toxicant in aquatic organisms.

Their characterization of two existing mouse models of MTM revealed signs consistent with an NMJ disorder, with pathological changes indicating a primary abnormality in the NMJ.

In primary mood and anxiety disorders, no structural pathological changes in the brain have been found, although abnormalities of neurotransmitter function have been postulated [ 85] and are consistent with the observed effects of some treatments [ 86].

Even before the primary signs of plaque deposition, memory impairment and pathological changes already appear in many AD mouse models [ 26].

Deposition of Aβ in the brain is believed to be the primary event in AD, initiating a cascade of pathological changes including formation of tau neurofibrillary tangles [ 9].

Consistent with the definition of AD onset, the same preventive intervention can be labeled as primary when dealing with clinical symptoms only or as secondary if prior pathological changes are considered.

Here, we provide evidence that the Aga2 type I collagen mutation directly causes pathological changes in heart and lung tissue that are bone-independent and are the primary cause of death in Aga2 severe.