Sentence examples for primary pathogenic pathways from inspiring English sources

Data from previously published studies in both in vivo and in vitro human and animal models suggests that four primary pathogenic pathways either independently or through interactions lead to PTB [18].

We have detected ER stress in some experimental paradigms but not in others, which fosters uncertainty about the role of this pathway as a primary pathogenic insult (8, 25– 25).

Here we show that, as opposed to primary pathogenic fungi (Histoplasma capsulatum), opportunistic fungal pathogens (Aspergillus and Rhizopus) trigger a common innate sensing pathway in human dendritic cells (DCs) that results in robust production of IL-23 and drives TH-17 responses.

In both pathologies, mammalian target of rapamycin (mTOR) pathway activation has been demonstrated [ 3– 6], possibly representing a primary pathogenic mechanism and a potential target for new treatment approaches [ 7].

However, whether or not the expression of Survivin is different between primary and secondary GBMs and the potential role of Survivin in tumorigenesis of GBMs in different pathogenic pathways have not been described to date.

From this joint effort, major pathogenic pathways emerged.

Preeclampsia is a complex syndrome with variable phenotypes that suggest differing underlying pathogenic pathways.

Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways.

The improvement of the knowledge of these interrelationships should contribute to elucidate pathogenic pathways and design effective treatments for NAFLD.

It is crucial to explore this association and identify clinical subgroups in both epilepsy and headache patients sharing common pathogenic pathways and possibly common therapeutic targets.

This could indicate that different pathogenic pathways are active in aggregate positive versus negative patients.