In HGPS, while the primary cause may be overproduction of Progerin, the secondary downstream causes and consequential effects are almost indistinguishable from normal aging, and therefore the condition appears to be very similar or indistinguishable from regular chronological aging.
MurA was found to be the primary target of bromoacetate and overproduction restored growth by outcompeting the toxic effects of this halogenated compound.
The rare protruding aux1-21 ARs were located at the hypocotyl PR junction, and showed a regular primary radial pattern, but with overproduction of xylem (Fig. 5C, arrows).
VSWTs' short-term overproduction capability is of primary concern for the transmission system operators (TSOs) in the process of restoring critical situations during large frequency excursions in power systems with high wind power penetration.
As described below, primary BAD is due to an overproduction of bile acids rather than malabsorption.
It has long been known that fibre differentiation or stem elongation is controlled by growth factors such as auxin, GA and brassinosteroids, and that overproduction of auxin decreases primary stem elongation in Arabidopsis [ 46].
Indeed, overproduction of opioid peptides in primary sensory neurones or spinal cord induced antihyperalgesic effects in various animal models of persistent pain.
In terms of understanding disease mechanisms and designing therapeutic strategies for muscular dystrophy, it is important to discern if this overproduction of ROS is a primary cause or secondary effect of the disease progression.
Furthermore, both the 1997 and 2003 human H5N1 isolates acquired the ability to induce an overproduction of pro-inflammatory cytokines by primary human macrophages in vitro (which could explain their pathogenicity) (Leo Poon, University of Hong Kong).
Britain has never faced levies for overproduction, unlike our main competitors Germany, Ireland and Denmark.
