Sentence examples for primary negative regulator from inspiring English sources

Guided by this information, we identified KEAP1 (also known as KLHL19), the primary negative regulator of NRF2, as a direct substrate of OGT We show that O-GlcNAcylation of KEAP1 at serine 104 is required for the efficient ubiquitination and degradation of NRF2.

Thus, our data supports UBP43 as a primary negative regulator of IFN-α signaling.

The tumor suppressor Rb is the primary negative regulator of E2F.

We then examined whether DAF-18, the primary negative regulator of PI3K signaling, was required for AIY neurodevelopment.

The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling.

MDM2 acts as a primary negative regulator of p53 by two major ways: (1) through ubiquitination of p53 to promote proteasome-mediated degradation; and (2) by directly binding to p53 and masking its transactivation domain.

Podocan and a Wnt-TCF pathway marker were differently expressed in human coronary restenotic versus primary lesions.Podocan appears to be a potent negative regulator of the migration and proliferation of both murine and human SMCs.

These observations confirm that PSTPIP2 is a negative regulator of megakaryopoiesis in primary cells.

Conversely, the negative regulator GSK3β was down-regulated.

This miRNA is one of the most abundant miRNAs in primary β-cells and was first discovered as a negative regulator of insulin secretion (Poy et al. 2004).

One of the master regulators of protein synthesis and negative regulator of autophagy is MTORC1.