Sentence examples for primary molecular target from inspiring English sources

Here we review recent strategies for developing disease-modifying therapies designed to limit or abolish the pathogenic activities of the primary molecular target in HD, the mutant HTT protein itself.

Regulatory and competitive pressure to reduce the QT interval prolongation risk of potential new drugs has led to focus on methods to test for inhibition of the human ether-a-go-go-related gene (hERG -encoded K+ chERG -encodedrimary molecular target underlying this safety issue.

The primary molecular target of NPAS2 is Per2, which was also found to be significantly modulated by vitamin D deficiency in the peri-implant tissue (Table 1).

This presents the obvious need for strategies in which an inhibitor of the primary molecular target and one or more inhibitors of dominant resistance mechanisms are deployed simultaneously or consecutively to enhance initial tumor cell killing or prolong an anti-tumor response.

There are many examples of chemically diverse pesticides that act on a common primary molecular target.

BCR-ABL signaling is responsible for the pathogenesis of CML and is the primary molecular target for disease therapy with imatinib mesylate (Glivec, Gleevec, IM), a TK inhibitor.

The primary molecular targets of cocaine, amphetamines, fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), sertraline (Zoloft), MDMA (Ecstasy), methylphenidate (Ritalin), tricyclic antidepressants, nomifesine and bupropion are neurotransmitter transporters of this class.

The primary molecular targets of pyrethroids are neuronal voltage-sensitive sodium channels (VSSCs) [ 6].

The primary molecular targets of MPH are plasma membrane dopamine and noradrenaline transporters [ 60].

We report on the cellular uptake and the primary molecular targets of a subclass of oxidized phosphatidylcholines.

Several attempts have already been made to identify the primary molecular targets of oxidized phospholipids in cells.