Sentence examples for primary molecular pathways from inspiring English sources

Previous work by our group demonstrates that in canine liver disease the primary molecular pathways associated with liver regeneration (e.g. the hepatocyte growth factor (HGF) signaling pathway) are highly comparable with those in rodents and humans [ 22- 24].

At least 3 primary molecular pathways involved in the progression of CRC have been identified, including the prevalent chromosomal instability (CIN) pathway (identified in up to 80% of cases), the CpG island methylator phenotype (CIMP) pathway, and microsatellite instability (MSI), resulting from the DNA mismatch repair (MMR) gene [ 18].

The primary molecular pathway(s) by which ATM gene leads to these alterations are not well known [ 32].

The main goal of genetic studies is to unravel molecular pathways underlying primary headache disorders, in order to discover new therapeutic targets.

In LN metastases, most genes were downregulated or showed equal expression with the levels found in primary tumours, possibly reflecting their motility behaviour requiring (temporarily) less molecular pathways compared with primary tumours.

Our data provide a platform to evaluate molecular pathways or primary cellular targets of compounds for further development of antitumor agents.

In the other study, which used WDTC, PDTC and ATC primary tumours, deregulation of different molecular pathways, such as the MAPK signalling pathway, focal adhesion and cell motility, cell proliferation and cell-cycle progression, was associated with dedifferentiation in PDTC and ATC (Montero-Conde et al, 2008).

Although usually indistinguishable histologically, distinct molecular pathways characterise the primary and secondary forms.

The shortcomings of the current standards of care highlighted above underscore the pressing need for rationally conceived therapies targeted to the specific molecular pathways deregulated in primary brain tumors.

The classic and invariable FOP phenotype of great toe malformations and progressive heterotopic endochondral ossification suggested that the primary molecular pathology involves the BMP signaling pathway.

The primary promise that the combination of understanding molecular pathways of disease and the complete human genome sequence would yield safer and more efficient medicines and revolutionize the way we treat patients has not been fulfilled to date.