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One of the primary methodological challenges facing such multisite trials is how to deal with site differences, and variability in treatment effects across sites.
Similar(59)
Such approach faces three main methodological challenges.
However, selection bias remains a main methodological challenge for longitudinal studies.
Low disease prevalence and lack of uniformity in reference standard in primary care creates methodological challenges in primary care level diagnostic accuracy studies.
Low disease prevalence and lack of uniform reference standards in primary care induce methodological challenges for investigating the diagnostic accuracy of a test.
The evaluation of a IM primary care model presents a number of methodological challenges.
Studies comparing the performance of specialist care to primary care have shown contradictory results, though there have been methodological challenges [ 12].
This article will discuss several methodological challenges in designing and conducting a pragmatic primary care based randomised controlled trial, based on our experiences in the DIAMOND-study and will discuss the rationale behind the choices we made.
We highlight methodological challenges in using intrahousehold decision making as the primary indicator to measure empowerment.
The primary health care context involves many stakeholders at multiple levels, creating significant conceptual and methodological challenges such as developing effective study designs and selecting appropriate outcomes.
This protocol is designed to meet the methodological challenges involved in evaluating this complex intervention (IM model of adult primary care) with as much rigor as possible.
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