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In this study, we demonstrated that NKDCs, functioning as immunostimulatory DCs, could be a primary mediator of the α-GC-mediated immune response.
The M1 macrophage subpopulation is considered as the primary mediator of inflammation whereas the M2 macrophage subpopulation is considered to be the primary mediator of wound healing and pathologic fibrosis.
The hydroxyl radical is the primary mediator of DNA damage by the indirect effect of ionizing radiation.
The primary mediator of endocannabinoid signaling is N-arachidonoylethanolamine (anandamide, or AEA), and 2-arachidonoylglycerol (2-AG) is another primary endocannabinoid [71, 78 80].
It also supports the biological role for HBP as a primary mediator of vascular leakage, an important pathophysiological mechanism in septic shock.
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases.
The tPA is the primary mediator of local intravascular fibrinolysis.
CD36 is the primary mediator of cholesterol accumulation in atherosclerosis induced by HIV PIs [12].
Among β-1 globulins, complement is the primary mediator of the antigen-antibody reaction.
Prophages are a primary mediator of GAS intra- and inter-serotype differences in virulence factor content [80].
Neutralizing antibodies directed against the HA glycoprotein are the primary mediator of protection against influenza virus infection [15], [16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com