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Primary loss of selenoproteins appears to be more consistent with the existing Drosophila data.
Our data therefore suggest that the primary loss of function in these IPEX mutants relates to dimerization and DNA binding.
It is also likely that the loss of these genes is a consequence of the primary loss of sour-sensing cells.
Accordingly, treatment of Aif-depleted human cells (Hep3B and HeLa cell lines) with antioxidants (N-acetyl-cysteine or MitoQ) failed to restore complex I integrity [29], suggesting primary loss of complex I, which might increase superoxide leakage.
Further studies will be needed to determine the relative contribution of secondary alterations in sex hormones and primary loss of calcium-sensing receptor responses to the observed bone phenotype in GPRC6A null mice.
Another pit fall is primary loss of CaP after its application.
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Primary loss and dysfunction of astrocytes may trigger demyelination, as seen in neuromyelitis optica, an inflammatory disease of the central nervous system.
A1 Primary Reveals Loss of Blacks Saturday's mayoral election may not have settled whether Hurricane Katrina overturned politics in New Orleans, but it made one thing clear: for now, the storm has swept away the dominance of the city's black vote.
Those two years run out as a resurgent tea party claims a boost from the shocking primary election loss of GOP majority leader Eric Cantor (R-Va).
Of 76 primary CRCs, loss of RASSF1A expression and/or K-ras mutations were detected in 77% cases.
Constitutive p100 overexpression causes an aberrant phenotype, as shown by the thickening of primary ducts, loss of epithelial cell organization and small areas of hyperplastic growth.
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