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The short range of positrons in tissue necessitates primary localisation of suspected tumour tissue either visually by the surgeon or by using a high-energy gamma detector.
The relation between bcl-2 protein expression and survival was small, depending on the primary localisation of the tumour (in lymph node of mucosae), and lacked a significant correlation with overall survival.
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The following clinical and biological variables were recorded: age, sex, body mass index, primary localisation, sites of metastasis, World Health Organisation (WHO) performance status (PS), Charlson comorbidity score (Charlson et al, 1987), haemoglobin, creatinin clearance (according to Cockroft method), alkaline phosphatase and carcinoembryonic antigen.
There were no significant differences between groups at baseline in age, tumour size, nodal status, ER or PgR status, histological grade, surgery, primary localisation, prior use of HRT, histological type, chemotherapy, radiotherapy or country.
To evaluate prognostic factors for secondary hepatic resection, the following baseline parameters were analysed: age, sex, KPS, localisation of primary tumour, T-stage of primary, N-stage of primary, resection of primary, development of metastases, localization of metastases, number of metastatic sites, adjuvant treatment, AP level, LDH levels, WBC count and treatment arm.
In the literature, 68Ga-DOTA-peptides are reported to be excellent candidates for imaging and staging patients with neuroendocrine tumours, including the localisation of primary tumours in patients with known NET metastasis (carcinoma of unknown primary origin) (Fig. 5) [45] 45].
SSRS is widely available and well established for the localisation of primary NETs.
However, imaging is used extensively for the localisation of primary neuroendocrine tumours, as well as in staging the tumour.
Administration of specific medications to treat symptoms should therefore start as soon as clinical and biochemical signs indicate the presence of hypersecretory NETs, even before the precise localisation of primary and metastatic lesions is confirmed.
All significant prognostic clinical parameters such as age, stage distribution and localisation of primary tumour did not differ from other international studies, in which no form of screening had taken place, or from the earlier Danish study.
The aim of this pilot study was to assess the degree of interobserver agreement and confidence in anatomical localisation of primary head and neck tumours and their metastases with F-FDG PET alone and with F-FDG PET/CT.
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