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Although conventional drug screens have yielded many effective drugs, there are nevertheless two primary limitations that restrict the opportunity to increase the development of new drugs and for which a signature-based approach might be successful.
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The circulation of liquid from the condenser to the evaporator is driven by the capillary action which is the primary limitation that governs the maximum heat transport capability of the device.
Indeed, one of the primary limitations is that we assessed exposure using PM mass alone and did not estimate associations with the constituent components of the mass that may be most related to the health effects.
One of our primary limitations was that we may not have had adequate sample size, particularly in the smaller homes, to see potentially significant changes in TTR and INR testing frequency.
The baseline/post evaluation design was the most pragmatic option but its primary limitation is that it cannot rule out the possibility that a factor other than the Beat da Binge program was causally related to the observed outcomes, even though there was no other intervention implemented in Yarrabah during the project period.
The primary limitation is that comparing a technically sophisticated ICU-like device that costs as much as $25,000 to another one below $10,000 could be considered as making no sense.
The benefit of such a technique is that we can amplify CRISPR spacer sequences from a wide array of different bacterial species that share the same repeat motifs, while the primary limitation is that we cannot ascribe the spacer sequences to any given bacterial species or strain.
The primary limitation is that WelTel Retain is a single-site study in a resource-limited setting; generalisability to other settings may be limited.
The primary limitation is that university faculty cannot edit student edTPA portfolios, provide candidates with alternative or corrected responses, or direct student teachers which video segments they should submit for evaluation.
The primary limitation is that all other information was self-reported.
The primary limitation is that the methods used to diagnose diabetes were different in each study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com