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Two primary isoforms of S6K1, p70 and p90, were detected in our liver samples.
The primary isoforms of glucose transporter in brain are GLUT1, detected at high concentrations in blood-brain barrier and glia; GLUT3 in neurons; and GLUT5 in microglia [ 108].
For example, LDH-A is one of the primary isoforms of LDH, which controls the transition of pyruvate to lactate of glycolysis and has a vital role in sustaining energy metabolism of tumor cell.
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The primary isoform of scrb-PB is not identified as belonging to the same functional neighbourhood since it has a distinct expression profile.
Calpain is a calcium ion-dependent cysteine protease, consisting of two primary isoforms (calpain1/calpain2) which mediate crucial cellular functions.
Although the regulation of VEGF expression is becoming well understood, its mode of action, particularly the regulation of expression and distribution of the three primary isoform (VEGF121, VEGF165 and VEGF189), remains unclear.
Cyclooxygenase-1 is the primary isoform responsible for the production of cytoprotective prostaglandins (PGE2 and PGI2) in the stomach.
The 'Expression Ratio' is the ratio of the average secondary isoform expression to the average primary isoform expression.
Conversely if a minor isoform is expressed at comparable levels to the primary one and at times or locations that the primary isoform is absent or reduced, then this could be a useful indicator of some additional functional roles.
Example of a secondary isoform with a low TS score when compared to the primary isoform.
Another caveat is that we define the primary isoform as the most expressed isoform.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com