In this system, the primary invasion occurred at a region of donor cleavage associated with weak pausing.
a Primary tumor invasion of the retroperitoneum (arrow), with a perforated hole (large arrow).
In contrast to secondary IBC, in primary IBC invasion of the dermis outside the lymphatic vessels is uncommon.
The process of tumour metastasis consists of detachment of cells from the primary tumour, invasion of extracellular matrix (ECM), intra- and extravasation, and growth at the secondary site.
Newer techniques such as PET/CT may improve accuracy but some collaboration is still likely to be useful for many patients, particularly when defining the extent of primary tumour invasion of the mediastinum.
Tumour metastasis is a multistep process requiring detachment of malignant cells from the primary tumour, invasion of blood or lymph vessels, interaction with endothelium, extravasation at distant sites and formation of new tumour foci [ 9, 12, 13].
Cellular motility is essential in the metastatic process, which requires cellular migration away from the primary tumour, invasion of surrounding tissue, entrance into the circulation, and then migration into a distant organ or tissue.
It is well known that the metastatic process consists of several stages: tumour cell escape from primary tumour, invasion of the vessels, migration, adhesion to the vascular endothelium, extravasation, and colonisation, all of which are essential for the development of clinically overt metastases.
These include the proliferation and detachment of tumour cells from the primary neoplasm, invasion of the surrounding extracellular matrix, angiogenesis, vascular or lymphatic dissemination, and eventually, homing of the tumour cells and proliferation at the new sites (Woodhouse et al, 1997; Hanahan and Weinberg, 2000; Liotta and Kohn, 2001).
The genetic data suggest that the mice of both primary invasions originated from related source populations.
