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In contrast, low-frequency TENS is ineffective in reducing primary hyperalgesia.
Intradermal (ID) capsaicin injection in humans induces spontaneous pain, flare, primary hyperalgesia, secondary hyperalgesia, and allodynia.
Primary hyperalgesia was quantified by determining mechanical (von Frey hairs) and thermal (Peltier thermode) pain thresholds.
Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats.
Conclusion: High-frequency TENS reduces primary hyperalgesia to heat and mechanical stimuli for up to 1 day after treatment.
High-frequency TENS significantly reduced the primary hyperalgesia to heat and mechanical stimuli when compared with controls receiving no TENS or treatment with low-frequency TENS.
Similar(21)
The mechanisms for the induction of primary mechanical hyperalgesia are unclear.
Pressure pain thresholds (PPTs) were reduced over the infused muscle with acidic infusion, defined as primary mechanical hyperalgesia.
Moreover, the same doses of SB239063 and SP600125 also exhibited different suppressive actions on the induction of primary heat hyperalgesia and MIH hypersensitivity.
However, the primary mechanical hyperalgesia of the inflamed knee joint still develops in ASIC3 −/− mice and is similar to ASIC3 +/+ mice.
Taken together, these data suggest that activation of p38 in the spinal cord preferentially contributes to the development of PSN and MIH hypersensitivity under pathological state, while spinal JNK signaling pathways might play more important roles in inducing primary heat hyperalgesia.
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