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Jigorel, E., Le Vee, M., Boursier-Neyret, C., Bertrand, M. & Fardel, O. Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Cianciaruso, C. et al. Primary human and rat beta-cells release the intracellular autoantigens gad65, ia-2, and proinsulin in exosomes together with cytokine-induced enhancers of immunity.
However, if primary human and rat hepatocytes have been well-characterized with respect to drug transporter expression and regulation, much less is known for primary mouse hepatocytes.
Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors.
Here, we present an analogous, but high-throughput, in vitro approach in which drugs are administered to a variety of cell types (primary human and rat hepatocytes and the human HepG2 cell line) across a landscape of inflammatory contexts containing LPS and cytokines TNF, IFNγ, IL-1α, and IL-6.
In the current study, we have compared the replication of HIV-1 in primary human and mouse T cells.
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Consistently, a soluble BL-derived polypeptide inhibited HCV infection of hepatoma cell lines, primary human hepatocytes and humanized liver mice.
Durafourt, B. A., Moore, C. S., Blain, M. & Antel, J. P. Isolating, culturing, and polarizing primary human adult and fetal microglia.
By comparing CD40 and Fas-mediated apoptosis and intracellular signalling in primary human cholangiocytes and three cholangiocyte cell lines.
These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes.
We show for the first time expression of the GLP-1R and the GIPR by primary human microglia and astrocytes.
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