Sentence examples for primary granules from inspiring English sources

Toxic granulations represent increased concentrations of antimicrobial compounds in the primary granules, and Döhle bodies are aggregates of endoplasmic reticulum; both are markers of PMN activation in bacterial infection 61.

The FTIR spectra of primary granules and processed LV3 Arboform® show maintaining of the initial functional molecular groups supporting a positive response of the material towards reuse.

By contrast, primary granules generally fuse either with the phagosome or the nucleus [50], the latter being part of the recently discovered NETotic fate of neutrophils.

Until recently, it was believed that, due to the high self-harming potential of primary granule enzymes, the content of primary granules was rarely if ever discharged actively in the extracellular environment during the normal course of an inflammatory response.

In these cells, mobilization of primary granules to the plasma membrane is not a passive outcome, but rather a finely orchestrated mechanism leading to a fate distinct from phagocytosis and NETosis (Fig. 1).

Meanwhile, reactive oxygen species produced by neutrophils including hypochlorous acid (bleach), a byproduct of the enzyme MPO exocytosed from primary granules at the same time as NE, can quickly and profoundly oxidize the lung microenvironment [129].

The mechanisms of the effect of process parameters on primary granule properties (size and density) were proposed.

The effects of the process parameters on the bulk powder properties and tablet dissolution were consistent with their proposed link to primary granule properties.

Based on primary granule exocytosis and scatter profiles, CF airway neutrophils could be divided into two subsets, with one of the subsets characterized by more salient increases in Glut1, ASCT2, PiT1, and PiT2 expression.

Understanding the impact of primary granule properties on bulk powder properties and final product critical quality attributes provides the basis for modulating granulation parameters in order to optimize product performance.

In a previous study, we showed that activation of a transfected human erythropoietin receptor (EPOR) in the murine myeloid cell line 32D resulted in the development of morphologic features of granulocytic differentiation and expression of the neutrophil primary granule protein myeloperoxidase.