Sentence examples for primary functional effect from inspiring English sources

This possible splice change cannot be the single primary functional effect, as rs4821480 is not significant when conditioned on rs2413396, but it could contribute to a more complex pattern of splice and possibly expression variation.

The primary functional effects of these CM mutants, when expressed together at the working myocyte level, are presently unknown.

The model employs vector addition to illustrate the merging of the primary functional effects of each distinct mutant allele in a given double heterozygous combination.

Functional imbalances, e.g., in force generation, might represent a unifying mechanism triggering a common pathological pathway in FHC for different mutations, despite variable primary functional effects [ 28, 37].

These observations suggest that the epigenetic status of primary cells may determine the functional effect of SYT-SSX, possibly including its transforming capacity.

A specific functional effect on primary human endothelial and alveolar epithelial cells has also been shown.

In a typical structure-function relation study, the primary structure of proteins or nucleic acids is changed by mutagenesis and its functional effect is measured via biochemical means.

The primary analysis was powered to assess changes in haemoglobin concentration, which limited the scope of this study to the functional effect of MMN supplementation on nutritional anaemia.

Predicting the functional effect of amino acid substitutions and indels.

¥Polymorphisms with demonstrated functional effect in vitro.

25 Sample size calculation is based on the primary hypothesis comparison between the functional effects of Mitii compared with standard care at 20 weeks on the AMPS.