Primary functional classes of the regulated genes were (i) efflux pumps, (ii) stress response, (iii) fatty acid, lipid, and derivatives biosynthesis, and (iv) hexose transport, ergosterol biosynthesis, and thiamine biosynthesis (Table 1).
Primary efficacy assessments for NYHA functional class and self-reported patient global assessment (PGA) are performed at weeks 4, 12 and 24.
Primary and secondary endpoints included NYHA functional class change from baseline and European Quality of Life-5 Dimensions (EQ-5D; EuroQol Group, Rotterdam, The Netherlands) questionnaire-based health-related quality of life (HRQoL).
Primary outcomes included quality of life, functional class, and all-cause hospital and emergency room admissions 12 months before compared with 12 months after enrolment; a secondary endpoint was patient satisfaction.
Baseline data were extracted from the patients' hospital records, and included the patients' age, sex, New York Heart Association NYHAA) functional class on admission, the primary cause of HF, laboratory data, chest X-ray findings, echocardiographic data, and medical history.
Baseline data were extracted from hospital records and included age, sex, New York Heart Association (NYHA) functional class on admission, the primary cause of HF, laboratory data, 12-leads resting electrocardiogram, echocardiographic data, and medical history.
54 The primary end points were self-reported Patient Global Assessment and NYHA functional class, both at week 24.
This can be applied to retrieval of all structures for a given functional class, e.g. all odorant molecules, in order to do primary research in a particular domain, e.g. smell perception.
The primary end point was a combined measure of improvement of at least one functional class and at least 10% in 6 min walk distance from baseline to week 12 (Table 1).
The primary endpoint was a composite of all-cause mortality, heart failure-related hospitalization, NYHA functional class, and Quality of Life score, at 1 year.
