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In Drosophila, while imaginal discs can retain their primary fate during extended periods of in vivo culture, a few examples were observed in which the cells would adjust to another disc fate, a process termed transdetermination [32].
The primary fate of pyruvate in the liver is carboxylation to form oxaloacetate, which is in rapid equilibrium with malate and fumarate.
Indeed, complete command of this primary fate choice may even be incompatible with the underlying nature of the pluripotent ground state (see below).
However, alanine's primary fate is transport to the liver; its production usually presages the transport of nitrogen back to the liver for disposal as urea.
Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli.
By contrast, a fate control strategy is minimum phase, because differentiation (down a primary fate pathway) and renewal can be suppressed simultaneously (through up-regulation of progression toward an alternative fate).
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P6.p, the VPC closest to the AC, adopts the primary vulval fate, while P5.p and P7.p, the two adjacent VPCs to P6.p, adopt the secondary vulval fate as a result of lateral signaling, which is mediated by the LIN-12/Notch pathway (Greenwald, 2005).
In a cruel twist of primary political fate, despite his wins, Santorum has the least number of actual delegates.
In contrast Delta, a ligand for Notch receptor, forces cells towards primary differentiation fate [16], [17].
This is in agreement with previous studies, showing that the primary metabolic fate of exogenous lactate uptake was subsequent oxidation [30].
By gain- and loss-of-function assays, we learned that NaRCs might be set as the primary differentiation fate by foxi3a/foxi3b function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com