The thorough dissection of morphologic, immunohistochemical and genomic intratumor hetero-geneity in our study illustrates that the primary co-existence of different growth patterns can be associated with divers biomarker expression and TP53 or CTNNB1 gene mutations among wild type tumor cells.
Substances are not the primary sense of existence but rather 'acts of existence' or processes.
Mr Pinter has got hold of a primary fact of existence.
But even if comradeship is its primary reason for existence, Masonry has its charitable side as well.
Participants (University of Chicago faculty, visitors, and graduate students) will seek to define a long-term agenda, identify secondary and primary sources whose existence in English is a desideratum, and assess the possibility of establishing a consortium, across universities, for the advancement of the studia humanitatis.
BS-BM was calculated by adding the scores (0 or 1) of three main prognostic factors: KPS, control of the primary tumor, and existence of extracranial metastases [ 13].
If confirmed in a larger cohort of primary cancers, the existence of distinct types of T-ICs in BC will have consequences for targeting such cells with drugs.
The remaining variables (physicians, nurses, medical appointments and population size), which alone presented a significant association with SMR, were no longer significant after adjustment for PPI, more than one primary healthcare centre, existence of a hospital and number of pharmacies in the county.
It is possible that, in primary culture, co-existence of variable types of cells including blood cells secret some cytokines or cell adhesion molecules in an autocrine or paracrine fashion, and support the adhesion and proliferation of SP cells.
In 1863, John Stuart Mill wrote: "The entire history of social improvement has been a series of transitions, by which one custom or institution after another, from being a supposed primary necessity of social existence, has passed into the rank of a universally stigmatised injustice and tyranny.
Annealing causes a significant growth of primary particles with the existence of internal pores within a particle.
