Sentence examples for primary events that from inspiring English sources

Thus, Snail shRNA may exert its anti-necrotic effects through preventing metabolic stress-induced loss of mitochondrial membrane potential, mitochondrial permeability transition, and metabolic stress-induced protein aggregation, which are the primary events that trigger necrosis, through its inhibitory effect on mitochondrial ROS production.

In this way, the metabolic changes could be primary events that activate or inhibit apoptotic process.

Although the CNS was initially considered an immunologically privileged site, one of the primary events that occur during CNS affecting autoimmune disease such as MS is the recruitment of immunocompetent lymphocytes to the brain [ 45].

Snail shRNA-mediated necrosis inhibition appeared to be linked to its ability to suppress metabolic stress-induced mitochondrial ROS production, loss of mitochondrial membrane potential, and mitochondrial permeability transition, which are the primary events that trigger necrosis.

Whether this is a primary event that causes a decline in health with advancing age or a result of a general decrease in metabolism in the elderly remains a topic for further investigation.

However, under certain circumstances, inflammation could be a primary event that leads to the neurodegenerative process.

The primary event that initiates the TGF- β-induced growth arrest may be associated with increased expression of p15INK4B, p21Cip1, and suppression of c-Myc expression.

When apoptosis is observed following treatment with anti-cancer drugs it may be a secondary event which occurs in lethally-damaged cells, leading to their lysis, rather than a primary event that leads to loss of reproductive integrity.

Nevertheless, it is also possible that a reverse scenario takes place and that, in Salmonella-infected cells, cytosolic AA starvation is the primary event that causes SCV membrane instability and NDP52 recruitment.

It is not certain whether mitochondrial dysfunction is the primary event that leads to oxidative stress and further mitochondrial damage or, conversely, whether oxidative stress contributes to mitochondrial dysfunction.

No reports were located to ascertain whether MAPK activation represents a primary event (that could trigger Mn toxicity) or if it occurs secondary to Mn-induced cellular dyshomeostasis/damage (triggered via other mechanisms, i.e., oxidative or metabolic changes).