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Three primary eruption periods in the history of the massif have been identified: ancestral, older and present.
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Clinical features include localized primary eruptions or generalized secondary eruptions, which can be eczematous or not.
Primary eruptions are characterized by recurrent eczematous lesions on the sites of direct contact with the items that release nickel, such as earlobes (use of earrings), wrists (use of watches), neck (use of necklaces) and umbilical region (jeans button).
To evaluate disturbances in primary tooth eruption and their management with nonpharmacological remedies.
Twin studies have provided insight into the genetic control of primary tooth eruption during childhood.
Primary tooth eruption is a complex and highly regulated process through which primary teeth enter the mouth and become visible.
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%.
We confirm association with six loci previously associated with primary tooth eruption (KCNJ2/KCNJ16, EDA, IGF2BP1, MSRB3, Chr6q21, 2q35) (6).
In contrast, a consistent relationship between delayed primary tooth eruption and malnutrition was found in numerous studies performed in younger children [ 22, 31– 31].
Genome-wide association analyses of primary tooth eruption variables were based on data collected from two prospective birth cohorts: ALSPAC and NFBC1966.
For the three loci (i.e. HMGA2, BMP4, MSRB3) associated with 'age at first tooth' at genome-wide significance, the allele associated with earlier primary tooth eruption was also associated with a greater number of permanent teeth.
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