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The primary endpoint analyzed was global cognition, involving a measure of developmental quotient or IQ.
The primary endpoint analyzed was 24-hour weighted mean glucose (WMG); secondary endpoints included fasting plasma glucose (FPG) and fructosamine.
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The results presented in Figure 1 are constrained to the larger study, where the most significant ALT elevations were observed (patient demographics in Supplementary Table S4. The primary endpoints analyzed were biomarkers (ALT, AST, and serum bilirubin) measured from serial serum samples.
Data for the primary endpoint was analyzed via chi-squared analyses; the secondary outcome measures were analyzed with a 2-tailed Repeated Measures analysis of variance (ANOVA), chi-squared, and/or independent or dependent t-tests, as appropriate.
The primary endpoint was analyzed with a logrank test.
The impact of several prognostic characteristics on the primary endpoint was analyzed.
The primary endpoint was analyzed by using the Cochran-Mantel-Haenszel (CMH) procedure adjusted for center.
The patients, who were excluded from the analysis of the primary endpoint, were analyzed for secondary endpoints.
As a secondary analysis to confirm robustness, the primary endpoint was analyzed using the Kaplan Meier method and the log-rank test.
The primary endpoint was analyzed using an analysis of covariance (ANCOVA) model, with treatment, baseline eGFR and number of previous anti-diabetes medications as fixed effects and baseline HbA1c and baseline AUC1-4h for PPG as linear covariates.
The latter was predesignated as the primary endpoint and analyzed using Wilcoxon's rank-sum test and PROC NPAR1WAY, with significant differences between the emollients declared at the 5% level.
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